Research Interests


Secondary metabolites from niche area (Sardinia, Mediterranean Alps) and from medicinal and poisonous plants. Secondary metabolites from edible plants and spices: identification of neutraceutical agents from local food plants.

Synthetic methodologies

Chemoselective modification of polyfunctional compounds (polyphenolics, phenolic alcohols, phenolic amines). Development of new protocols of functional group modification.

Medicinal chemistry of natural products

Identification, synthesis, and chemical modification of bioactive endolipids (endocannabinoids, endovanilloids, endogenous eicosanoids) and their natural products mimics (cannabinoids, capsaicinoids).

Synthesis of molecular probes to explore various classes of TRP receptors (TRPV1, TRPM8, TRPA1, TRPV4) and of bitter receptors (hTAS2R family).

Synthesis of molecules aimed at various oncological end-points (tubulin, PgP, NF-?B, PKC, Kinases) and at achieving HIV de-latentization (prostratinoids).

Identification of non-steroid natural products interacting with estrogen- and progesterone receptors, and exploitation of their biomedical potential.

our team

Giovanni Appendino

Full professor

Alberto Minassi

Associated professor

  • Post-doc researchers

    Diego Caprioglio

    Alberto Pagani

    Federica Rogati

  • Ph.D. students

    Simone Gaeta

    Daiana Mattoteia

  • Junior scientists

    Patrizia Marotta

  • Undergraduate students

    Vittorio Del Grosso

    Chiara Maioli

Isolation: Chemical Diversity from Biodiversity

Synthesis: Chemical Diversity from Ingenuity and Technology

New synthetic strategies

Total Synthesis

Study of reaction mechanisms: The Michael reaction

Modification of Natural Products Leads

Collaborations & Fundings

  • Spectroscopy

    Orazio Taglialatela-Scafati (UniversitĂ  di Napoli)

  • Access to plant biodiversity

    Gianpaolo Grassi (CRA, Rovigo - IT)

    Mauro Ballero (University of Cagliari, Cagliari - IT)

    Dado Luciano (IT)

  • Biological evaluation

    Eduardo Munoz (University of Cordoba, Cordoba - SP)

    Oliver Werz (University of Jena, Jena - DE)

    Vincenzo Di Marzo, Luciano De Petrocellis (CNR, Naples - IT)

    Pierangelo Geppetti (UniversitĂ  di Firenze, Florence - IT)

    Wolfgang Mayerhof (German Nutrition Center, Potsdam - DE)

  • Fundings

    UniversitĂ  del Piemonte Orientale (Vercelli - IT)

    Emerald Health Terapeutics (CAN)

    EU- TriForC

    Indena S.p.A. (Milan - IT)

    Ecobiotics (Yungaburra - AUS)

    Versalis (San Donato Milanese - IT)


Last five

  • 223) Adela GarcĂ­a-MartĂ­n,MartĂ­n Garrido-RodrĂ­guez, Carmen Navarrete, Diego Caprioglio, BelĂ©n Palomares, Jim De Mesa, Alain Rollland, Giovanni Appendino, Eduardo Muñoz, Biochemical Pharmacology, In Press,

    222) A. Rosa, D. Caprioglio, R. Isola, M. Nieddu, G. Appendino and A. M. Falchi, Food Funct., 2019, Advance Article

    221) Federica Rogati, Estrella Millán, Giovanni Appendino, Alejandro Correa, Diego Caprioglio, Alberto Minassi, and Eduardo Muñoz, ACS Med. Chem. Lett., Article ASAP, DOI: 10.1021/acsmedchemlett.8b00604

    220) Lopatriello A., Caprioglio D., Minassi A., Schiano Moriello A., Formisano C., De Petrocellis L., Appendino G., Taglialatela-Scafati O., (2018) Bioorganic and Medicinal Chemistry, 26 (15) , pp. 4532-4536

    219) Pollastro F, Caprioglio D, Marotta P, Moriello AS, De Petrocellis L, Taglialatela-Scafati O, Appendino G, Journal of Natural Products Volume 81, Issue 3, 23 March 2018, Pages 630-633


  • New paper on TriForC project: A pipeline for the discovery, sustainable production and commercial utilisation of known and novel high-value triterpenes with new or superior biological activities (Impact, Volume 2017, Number 1, January 2017, pp. 37-39(3)

    Cover Picture: Phytocannabinoids: a unified critical inventory (Nat. Prod. Rep., 12/2016)

    Cover Picture: Plant volatiles: Production, function and pharmacology (Nat. Prod. Rep., 08/2011)

    Cover Picture: Cannabimovone, a Cannabinoid with a Rearranged Terpenoid Skeleton from Hemp (Eur. J. Org. Chem. 11/2010)

    Cover Picture: Synthesis and Biological Evaluation of Phorbol-Resiniferatoxin (RTX) Hybrids (Eur. J. Org. Chem. 16/2004)

    Cover Picture: Oxidative Fragmentation of the Bridged β-Triketone Core of Hyperforin (Eur. J. Org. Chem. 6/2004)

    Cover Picture: Journal of Natural Products, January 2003, Volume 66, Issue 1

    Cover Picture: Synthesis and Evaluation of 14-Nor-A-secotaxoids (Eur. J. Org. Chem, 02/2002)